Researchers weave human tissue into new blood vessels

Researchers use threads made from engineered human tissue to braid blood vessels, which could one day help repair diseased or damaged blood vessels.
Dr. Nicolas L’Heureux, Research Director of Inserm/University of Bordeaux, France, said: “The blood vessel is just one of the methods for tissue engineering using our new fabric technology.” “It can be made by weaving, weaving or weaving thread almost anything Shape, and can well control the mechanical properties of the final product.”
Synthetic vascular grafts made of woven synthetic polymer yarns are sometimes used to replace diseased arteries. However, the human body recognizes polymers as foreign bodies, which can cause blood to clot on these grafts and form scars that can block the tubes. Since blood vessels created using the new textile-based method do not require any synthetic materials, they are likely to be accepted and become part of the human body.
L’Heureux is scheduled to present the research at the annual meeting of the American Anatomical Association in San Diego this month. Although the meeting held concurrently with the 2020 Experimental Biology Conference was cancelled due to the 2020 COVID-19 epidemic, the abstract of the research team has been published in this month’s FASEB Journal.
The thread used in the new textile method developed by L’Heureux’s research team is made of a biological material called a cell assembly matrix (CAM). CAM is mainly collagen, the most abundant protein in the human body, and the protein that makes tissues and organs have mechanical strength. CAM is recognized by the human body because it is completely human and has not been chemically modified.
In this new study, the researchers showed that they can make yarn by cutting CAM sheets into ribbons that can be used directly or twisted into threads. They use these threads to weave blood vessels with excellent mechanical properties without any synthetic scaffolding or chemical treatment.
L’Heureux said: “Gluing the CAM layers together is time-consuming and expensive.” “The new textile assembly method is not only more versatile, but also has the potential for automation, which will make it faster, easier and cheaper to use. ”
Since the collagen scaffold is an essential part of most organs, CAM can be used to quickly initiate the regeneration of many tissues and organs. So far, it has been used for laboratory-grown skin of burn patients and a guide to help repair nerve damage.
Researchers are now building other blood vessel prototypes and learn more about the best way to handle CAM lines and ribbons. They will soon begin testing vascular grafts in animals as a step in the final clinical trials in humans.
You can rest assured that our editorial staff will closely monitor every feedback sent and will take appropriate action. Your opinion is very important to us.
Your email address is only used to let the recipient know who sent the email. Neither your address nor the recipient’s address will be used for any other purpose. The information you enter will be displayed in your email, and Medical Xpress will not retain this information in any form.
Send weekly and/or daily updates to your inbox. You can unsubscribe at any time, and we will never share your details with third parties.
This website uses cookies to assist navigation, analyze your use of our services and provide content from third parties. By using our website, you acknowledge that you have read and understood our privacy policy and terms of use.


Post time: Oct-17-2020
WhatsApp Online Chat !